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Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.

Publication ,  Journal Article
Soher, BJ; Hurd, RE; Sailasuta, N; Barker, PB
Published in: Magn Reson Med
September 1996

Data from a previously published, multi-site trial (P.G. Webb, N. Sailasuta, S.J. Kohler, T. Raidy, R.A. Moats, R.E. Hurd. Automated single-voxel proton MRS: technical development and multisite verification. Magn. Reson. Med. 31, 365-373 (1994)) of a fully automatic, single-voxel, proton spectroscopy package (PROBE/SV, GE Medical Systems) was re-analyzed in terms of absolute metabolite concentrations using the cerebral water signal as an internal reference. In 100 spectra from parietal white matter in normal volunteers ranging in age from 22 to 34 years at eight sites, overall concentrations of choline (Cho) creatine (Cr), and N-acetyl-aspartate (NAA) resonances were found to be 2.00 +/- 0.50, 8.43 +/- 1.28, and 12.55 +/- 1.76 mumol/g wet weight, respectively. These values are in good general agreement with previously published values from quantitative, single-voxel studies. Metabolite concentrations for NAA, Cr, and Cho across all sites had standard deviations of 14.1%, 14.9%, and 25.1%, respectively. Quantitation of PROBE data sets is routinely possible by using the cerebral water signal as an internal reference.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

September 1996

Volume

36

Issue

3

Start / End Page

335 / 339

Location

United States

Related Subject Headings

  • Water
  • Reference Values
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Cerebral Cortex
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

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Soher, B. J., Hurd, R. E., Sailasuta, N., & Barker, P. B. (1996). Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med, 36(3), 335–339. https://doi.org/10.1002/mrm.1910360302
Soher, B. J., R. E. Hurd, N. Sailasuta, and P. B. Barker. “Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.Magn Reson Med 36, no. 3 (September 1996): 335–39. https://doi.org/10.1002/mrm.1910360302.
Soher BJ, Hurd RE, Sailasuta N, Barker PB. Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med. 1996 Sep;36(3):335–9.
Soher, B. J., et al. “Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.Magn Reson Med, vol. 36, no. 3, Sept. 1996, pp. 335–39. Pubmed, doi:10.1002/mrm.1910360302.
Soher BJ, Hurd RE, Sailasuta N, Barker PB. Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med. 1996 Sep;36(3):335–339.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

September 1996

Volume

36

Issue

3

Start / End Page

335 / 339

Location

United States

Related Subject Headings

  • Water
  • Reference Values
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Cerebral Cortex
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering