Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution.

Journal Article (Journal Article)

A k-space-time Bayesian statistical reconstruction method (K-Bayes) is proposed for the reconstruction of metabolite images of the brain from proton (1H) magnetic resonance (MR) spectroscopic imaging (MRSI) data. K-Bayes performs full spectral fitting of the data while incorporating structural (anatomical) spatial information through the prior distribution. K-Bayes provides increased spatial resolution over conventional discrete Fourier transform (DFT) based methods by incorporating structural information from higher resolution coregistered and segmented structural MR images. The structural information is incorporated via a Markov random field (MRF) model that allows for differential levels of expected smoothness in metabolite levels within homogeneous tissue regions and across tissue boundaries. By further combining the structural prior model with a k -space-time MRSI signal and noise model (for a specific set of metabolites and based on knowledge from prior spectral simulations of metabolite signals), the impact of artifacts generated by low-resolution sampling is also reduced. The posterior-mode estimates are used to define the metabolite map reconstructions, obtained via a generalized expectation-maximization algorithm. K-Bayes was tested using simulated and real MRSI datasets consisting of sets of k-space-time-series (the recorded free induction decays). The results demonstrated that K-Bayes provided qualitative and quantitative improvement over DFT methods.

Full Text

Duke Authors

Cited Authors

  • Kornak, J; Young, K; Soher, BJ; Maudsley, AA

Published Date

  • July 2010

Published In

Volume / Issue

  • 29 / 7

Start / End Page

  • 1333 - 1350

PubMed ID

  • 20304734

Pubmed Central ID

  • PMC2911978

Electronic International Standard Serial Number (EISSN)

  • 1558-254X

Digital Object Identifier (DOI)

  • 10.1109/TMI.2009.2037956


  • eng

Conference Location

  • United States