Acute stroke: evaluation with serial proton MR spectroscopic imaging.

Journal Article (Journal Article)

PURPOSE: To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings with those of conventional MR imaging. MATERIALS AND METHODS: A patient with middle cerebral artery stroke underwent conventional proton-density (PD)- and T2-weighted MR imaging, MR angiography, and multisection proton two-dimensional MR spectroscopic imaging over a period of 3 hours to 5 months after symptom onset. RESULTS: On 3-hour MR images, no abnormal signal intensity change was detectable. Spectroscopic images obtained at 24 hours showed localized elevation of cerebral lactate levels. In most regions with high lactate levels, infarction subsequently occurred. In the chronic stage (5 months), the infarct was associated with reduced N-acetylaspartate levels, increased choline levels, and absence of lactate. CONCLUSION: Spectroscopic imaging enables mapping of ischemic and infarcted brain regions with greater sensitivity than does conventional MR imaging.

Full Text

Duke Authors

Cited Authors

  • Barker, PB; Gillard, JH; van Zijl, PC; Soher, BJ; Hanley, DF; Agildere, AM; Oppenheimer, SM; Bryan, RN

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 192 / 3

Start / End Page

  • 723 - 732

PubMed ID

  • 8058940

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.192.3.8058940


  • eng

Conference Location

  • United States