Skip to main content

Genetic dissection of the mouse CNS using magnetic resonance microscopy.

Publication ,  Journal Article
Badea, A; Johnson, GA; Williams, RW
Published in: Curr Opin Neurol
August 2009

PURPOSE OF REVIEW: Advances in magnetic resonance microscopy (MRM) make it practical to map gene variants responsible for structural variation in brains of many species, including mice and humans. We review results of a systematic genetic analysis of MRM data using as a case study a family of well characterized lines of mice. RECENT ADVANCES: MRM has matured to the point that we can generate high contrast, high-resolution images even for species as small as a mouse, with a brain merely 1/3000th the size of humans. We generated 21.5-micron data sets for a diverse panel of BXD mouse strains to gauge the extent of genetic variation, and as a prelude to comprehensive genetic and genomic analyses. Here we review MRM capabilities and image segmentation methods; heritability of brain variation; covariation of the sizes of brain regions; and correlations between MRM and classical histological data sets. SUMMARY: The combination of high throughput MRM and genomics will improve our understanding of the genetic basis of structure-function correlations. Sophisticated mouse models will be critical in converting correlations into mechanisms and in determining genetic and epigenetic causes of differences in disease susceptibility.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

August 2009

Volume

22

Issue

4

Start / End Page

379 / 386

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Models, Animal
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Genomics
  • Brain Mapping
  • Brain
  • Animals
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Badea, A., Johnson, G. A., & Williams, R. W. (2009). Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol, 22(4), 379–386. https://doi.org/10.1097/WCO.0b013e32832d9b86
Badea, Alexandra, G Allan Johnson, and Robert W. Williams. “Genetic dissection of the mouse CNS using magnetic resonance microscopy.Curr Opin Neurol 22, no. 4 (August 2009): 379–86. https://doi.org/10.1097/WCO.0b013e32832d9b86.
Badea A, Johnson GA, Williams RW. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol. 2009 Aug;22(4):379–86.
Badea, Alexandra, et al. “Genetic dissection of the mouse CNS using magnetic resonance microscopy.Curr Opin Neurol, vol. 22, no. 4, Aug. 2009, pp. 379–86. Pubmed, doi:10.1097/WCO.0b013e32832d9b86.
Badea A, Johnson GA, Williams RW. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol. 2009 Aug;22(4):379–386.

Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

August 2009

Volume

22

Issue

4

Start / End Page

379 / 386

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Models, Animal
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Genomics
  • Brain Mapping
  • Brain
  • Animals
  • 3209 Neurosciences