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Imaging drug resistance with radiolabeled molecules.

Publication ,  Journal Article
Vaidyanathan, G; Zalutsky, MR
Published in: Curr Pharm Des
2004

A major obstacle to successful cancer chemotherapy is drug resistance. Multidrug resistance (MDR) is often seen with chemotherapeutic agents such as anthracycline derivatives, vinca alkaloids and taxanes. Multiple aspects of cellular biochemistry have been implicated in the MDR process. Cellular mechanisms of resistance are due to the presence of efflux pumps, P-glycoprotein (P-gp) and multiple resistance-associated protein (MRP), which belong to the ATP-binding cassette (ABC) family of transporters. Another form of drug resistance is involved in the chemotherapy of cancers with alkylating agents such as nitrosourea derivatives and nitrogen mustards. The cytotoxicity of these agents is primarily due to alkylation of the DNA guanine residues at their O6-position, which leads, via a cascade of events, to DNA strand breaks. The DNA repair protein, alkylguanine-DNA alkyl transferase (AGT) removes the alkyl groups from the lesions stoichiometrically to a cysteine in its active site. This process is irreversible and results in the degradation of the protein and its recovery is entirely from de novo synthesis. Noninvasive methodologies for monitoring the transport activity of these efflux pumps and determining tumor content of AGT could serve as critical tools for optimizing chemotherapeutic protocols on a patient-specific basis and gaining an understanding of the dynamics of resistance in living patients. In this review, we will describe the efforts made to date to synthesize radioactive probes of chemotherapy resistance and their use to quantitate these transporters and DNA repair protein by radionuclide imaging.

Duke Scholars

Published In

Curr Pharm Des

DOI

ISSN

1381-6128

Publication Date

2004

Volume

10

Issue

24

Start / End Page

2965 / 2979

Location

United Arab Emirates

Related Subject Headings

  • Tomography, Emission-Computed
  • Radiopharmaceuticals
  • Neoplasms
  • Multidrug Resistance-Associated Proteins
  • Medicinal & Biomolecular Chemistry
  • Humans
  • Drug Resistance, Neoplasm
  • Drug Resistance, Multiple
  • Antineoplastic Agents
  • Animals
 

Citation

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Vaidyanathan, G., & Zalutsky, M. R. (2004). Imaging drug resistance with radiolabeled molecules. Curr Pharm Des, 10(24), 2965–2979. https://doi.org/10.2174/1381612043383449
Vaidyanathan, G., and M. R. Zalutsky. “Imaging drug resistance with radiolabeled molecules.Curr Pharm Des 10, no. 24 (2004): 2965–79. https://doi.org/10.2174/1381612043383449.
Vaidyanathan G, Zalutsky MR. Imaging drug resistance with radiolabeled molecules. Curr Pharm Des. 2004;10(24):2965–79.
Vaidyanathan, G., and M. R. Zalutsky. “Imaging drug resistance with radiolabeled molecules.Curr Pharm Des, vol. 10, no. 24, 2004, pp. 2965–79. Pubmed, doi:10.2174/1381612043383449.
Vaidyanathan G, Zalutsky MR. Imaging drug resistance with radiolabeled molecules. Curr Pharm Des. 2004;10(24):2965–2979.
Journal cover image

Published In

Curr Pharm Des

DOI

ISSN

1381-6128

Publication Date

2004

Volume

10

Issue

24

Start / End Page

2965 / 2979

Location

United Arab Emirates

Related Subject Headings

  • Tomography, Emission-Computed
  • Radiopharmaceuticals
  • Neoplasms
  • Multidrug Resistance-Associated Proteins
  • Medicinal & Biomolecular Chemistry
  • Humans
  • Drug Resistance, Neoplasm
  • Drug Resistance, Multiple
  • Antineoplastic Agents
  • Animals