No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue.

Journal Article (Journal Article)

Radioiodinated meta-iodobenzylguanidine (MIBG) is used in the diagnosis and therapy of various neuroendocrine tumors. As a part of our efforts to develop an MIBG analogue with improved characteristics for these applications, a synthesis of 3-[131I]iodo-4-methylbenzylguanidine ([131I]MeIBG) was developed. Unlabeled MeIBG and the tin precursor, N, N'-(bis-tert-butyloxycarbonyl)-N-(4-methyl-3-trimethylstannylbenzyl) guanidine were synthesized in two steps from 3-iodo-4-methylbenzylalcohol. Radioiodinated MeIBG was synthesized at a no-carrier-added level by the iododestannylation of the tin precursor in about 85% radiochemical yield. The accumulation of [131I]MeIBG (38.9+/-3.0% of input counts) by human neuroblastoma SK-N-SH cells in vitro was 87% that of [125I]MIBG (44.5+/-3.0%) and a number of Uptake-1 inhibiting conditions reduced the uptake of both tracers in this cell line to a similar degree suggesting that introduction of a methyl substituent at the 4-position of MIBG did not adversely affect its biological characteristics.

Full Text

Duke Authors

Cited Authors

  • Vaidyanathan, G; Affleck, DJ; Zalutsky, MR

Published Date

  • March 2005

Published In

Volume / Issue

  • 62 / 3

Start / End Page

  • 435 - 440

PubMed ID

  • 15607920

International Standard Serial Number (ISSN)

  • 0969-8043

Digital Object Identifier (DOI)

  • 10.1016/j.apradiso.2004.07.001


  • eng

Conference Location

  • England