Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.
Journal Article (Journal Article;Review)
An attractive feature of targeted radionuclide therapy is the ability to select radionuclides and targeting vehicles with characteristics that are best suited for a particular clinical application. One combination that has been receiving increasing attention is the use of monoclonal antibodies (mAbs) specifically reactive to receptors and antigens that are expressed in tumor cells to selectively deliver the alpha-particle-emitting radiohalogen astatine-211 (211At) to malignant cell populations. Promising results have been obtained in preclinical models with multiple 211At-labeled mAbs; however, translation of the concept to the clinic has been slow. Impediments to this process include limited radionuclide availability, the need for suitable radiochemistry methods operant at high activity levels and lack of data concerning the toxicity of alpha-particle emitters in humans. Nonetheless, two clinical trials have been initiated to date with 211At-labeled mAbs, and others are planned for the near future.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Reardon, DA; Pozzi, OR; Vaidyanathan, G; Bigner, DD
Published Date
- October 2007
Published In
Volume / Issue
- 34 / 7
Start / End Page
- 779 - 785
PubMed ID
- 17921029
Pubmed Central ID
- PMC2083568
International Standard Serial Number (ISSN)
- 0969-8051
Digital Object Identifier (DOI)
- 10.1016/j.nucmedbio.2007.03.007
Language
- eng
Conference Location
- United States