A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate.

Journal Article (Journal Article)

An isocratic chiral HPLC method was developed for the separation of tolterodine tartarate enantiomers. The mobile phase consists of n-hexane and isopropyl alcohol in the ratio of 980:20 (v/v) with 1 ml diethylamine and 0.6 ml trifluoroacetic acid. Chiralcel OD-H (250 mm x 4.6mm) column was used at constant room temperature. Flow rate was kept at 0.5 ml/min. This method is capable of detecting the S-isomer up to 0.1 microg/ml. The method was validated in terms of linearity, precision, limit of detection (LOD) and limit of quantification (LOQ).

Full Text

Duke Authors

Cited Authors

  • Kumar, YR; Ramulu, G; Vevakanand, VV; Vaidyanathan, G; Srinivas, K; Kumar, MK; Mukkanti, K; Reddy, MS; Venkatraman, S; Suryanarayana, MV

Published Date

  • September 3, 2004

Published In

Volume / Issue

  • 35 / 5

Start / End Page

  • 1279 - 1285

PubMed ID

  • 15336373

International Standard Serial Number (ISSN)

  • 0731-7085

Digital Object Identifier (DOI)

  • 10.1016/j.jpba.2004.03.026

Language

  • eng

Conference Location

  • England