Nerve terminal remodeling visualized in living mice by repeated examination of the same neuron.

Journal Article (Journal Article)

The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or the synapses on them; these procedures could therefore be repeated after an arbitrary period. Observations of the same neurons at intervals of up to 3 weeks indicate that the pattern of preganglionic terminals on many of these nerve cells gradually changes.

Full Text

Duke Authors

Cited Authors

  • Purves, D; Voyvodic, JT; Magrassi, L; Yawo, H

Published Date

  • November 20, 1987

Published In

Volume / Issue

  • 238 / 4830

Start / End Page

  • 1122 - 1126

PubMed ID

  • 3685967

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3685967


  • eng

Conference Location

  • United States