Single-shot dual-z-shimmed sensitivity-encoded spiral-in/out imaging for functional MRI with reduced susceptibility artifacts.

Journal Article (Journal Article)

Blood oxygenation level-dependent (BOLD) functional MRI (fMRI) can be severely hampered by signal loss due to susceptibility-induced static magnetic field (B(0)) inhomogeneities near air/tissue interfaces. A single-shot spiral-in/out sequence with a z-shim gradient embedded between the two acquisitions was previously proposed to efficiently recover the signal. However, despite promising results, this technique had several limitations, which are addressed here as follows. First, by adding a second z-shim gradient before the spiral-in acquisition and optimizing both z-shim gradients slice-by-slice, a significantly more uniform signal recovery can be achieved. Second, by acquiring a B(0) map, the optimal z-shim gradients can be directly, efficiently, and accurately determined for each subject. Third, by complementing the z-shimming approach with sensitivity encoding (SENSE), the in-plane spatial resolution can be increased and, hence, susceptibility artifacts further reduced, while maintaining a high temporal resolution for fMRI applications. These advantages are demonstrated in human functional studies.

Full Text

Duke Authors

Cited Authors

  • Truong, T-K; Song, AW

Published Date

  • January 2008

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 221 - 227

PubMed ID

  • 18050341

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.21473


  • eng

Conference Location

  • United States