Lorentz effect imaging of ionic currents in solution.

Published

Journal Article

Current functional MRI techniques relying on hemodynamic modulations are inherently limited in their ability to accurately localize neural activity in space and time. To address these limitations, we previously proposed a novel technique based on the Lorentz effect and demonstrated its ability to directly image minute electrical activity with a millisecond temporal resolution in gel phantoms containing conductive wires as well as in the human median nerve in vivo. To better characterize its contrast mechanism and ultimately further improve its sensitivity for in vivo applications, we now apply this technique to image ionic currents in solution, which serve as a better model for neural conduction in biological systems than the electronic currents in conductive wires used in previous phantom studies. Our results demonstrate that ionic currents with durations and current densities on the same order of magnitude as those induced by neuroelectric activity in nerve fibers and in the brain can be detected.

Full Text

Duke Authors

Cited Authors

  • Truong, T-K; Avram, A; Song, AW

Published Date

  • March 2008

Published In

Volume / Issue

  • 191 / 1

Start / End Page

  • 93 - 99

PubMed ID

  • 18180187

Pubmed Central ID

  • 18180187

International Standard Serial Number (ISSN)

  • 1090-7807

Digital Object Identifier (DOI)

  • 10.1016/j.jmr.2007.12.005

Language

  • eng

Conference Location

  • United States