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Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide.

Publication ,  Journal Article
Ram, S; Ehrenkaufer, RE; Spicer, LD
Published in: Int J Rad Appl Instrum A
1989

A new synthesis is described for the production of the positron emitting radiopharmaceutical R-(+)-7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-N-[11C]methyl-1-phenyl-1H- 3-benzazepine (SCH 23390, 2a). This novel method involves reductive carboxylation, in which [11C]CO2 is reacted with the trimethylsilyl derivative of the desmethyl compound (SCH 24518, 1a) followed by treatment with lithium aluminum hydride, to afford no carrier added 11C-labeled SCH 23390. The procedure gave chemically and radiochemically pure 11C-labeled SCH 23390 in 53-72% radiochemical yield with an unoptimized specific activity of 40 Ci/mmol within 45-50 min from the end of bombardment.

Duke Scholars

Published In

Int J Rad Appl Instrum A

DOI

ISSN

0883-2889

Publication Date

1989

Volume

40

Issue

5

Start / End Page

425 / 427

Location

England

Related Subject Headings

  • Isotope Labeling
  • Dopamine Antagonists
  • Carbon Radioisotopes
  • Carbon Dioxide
  • Benzazepines
 

Citation

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Ram, S., Ehrenkaufer, R. E., & Spicer, L. D. (1989). Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide. Int J Rad Appl Instrum A, 40(5), 425–427. https://doi.org/10.1016/0883-2889(89)90210-4
Ram, S., R. E. Ehrenkaufer, and L. D. Spicer. “Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide.Int J Rad Appl Instrum A 40, no. 5 (1989): 425–27. https://doi.org/10.1016/0883-2889(89)90210-4.
Ram S, Ehrenkaufer RE, Spicer LD. Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide. Int J Rad Appl Instrum A. 1989;40(5):425–7.
Ram, S., et al. “Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide.Int J Rad Appl Instrum A, vol. 40, no. 5, 1989, pp. 425–27. Pubmed, doi:10.1016/0883-2889(89)90210-4.
Ram S, Ehrenkaufer RE, Spicer LD. Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide. Int J Rad Appl Instrum A. 1989;40(5):425–427.

Published In

Int J Rad Appl Instrum A

DOI

ISSN

0883-2889

Publication Date

1989

Volume

40

Issue

5

Start / End Page

425 / 427

Location

England

Related Subject Headings

  • Isotope Labeling
  • Dopamine Antagonists
  • Carbon Radioisotopes
  • Carbon Dioxide
  • Benzazepines