Use of gel filtration in the preparation of biological fluids for magnetic resonance spectroscopy.

Journal Article (Journal Article)

Analysis of biological fluids by proton magnetic resonance spectroscopy is often complicated by dynamic range problems created from the large water resonance. Gel filtration chromatography is found to be a simple and nondestructive method for exchanging D2O for H2O and for removing low molecular weight molecules from both plasma and urine, significantly improving subsequent one- and two-dimensional MRS spectra.

Full Text

Duke Authors

Cited Authors

  • Hoffman, DW; Venters, RA; Shedd, SF; Spicer, LD

Published Date

  • March 1990

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 507 - 513

PubMed ID

  • 2157933

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910130319


  • eng

Conference Location

  • United States