Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.

Journal Article

Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.

Full Text

Duke Authors

Cited Authors

  • Ram, S; Spicer, LD

Published Date

  • 1989

Published In

Volume / Issue

  • 40 / 5

Start / End Page

  • 413 - 416

PubMed ID

  • 2548973

International Standard Serial Number (ISSN)

  • 0883-2889

Language

  • eng

Conference Location

  • England