Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

Journal Article (Journal Article)

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Full Text

Duke Authors

Cited Authors

  • Steinbach, WJ; Cramer, RA; Perfect, BZ; Henn, C; Nielsen, K; Heitman, J; Perfect, JR

Published Date

  • August 2007

Published In

Volume / Issue

  • 51 / 8

Start / End Page

  • 2979 - 2981

PubMed ID

  • 17502415

Pubmed Central ID

  • PMC1932494

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.01394-06

Language

  • eng

Conference Location

  • United States