Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Journal Article (Journal Article)
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
Full Text
Duke Authors
Cited Authors
- Steinbach, WJ; Cramer, RA; Perfect, BZ; Henn, C; Nielsen, K; Heitman, J; Perfect, JR
Published Date
- August 2007
Published In
Volume / Issue
- 51 / 8
Start / End Page
- 2979 - 2981
PubMed ID
- 17502415
Pubmed Central ID
- PMC1932494
International Standard Serial Number (ISSN)
- 0066-4804
Digital Object Identifier (DOI)
- 10.1128/AAC.01394-06
Language
- eng
Conference Location
- United States