Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

Published

Journal Article

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Full Text

Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Heitman, Joseph
Perfect, John Robert
Steinbach, William J.

Cited Authors

Steinbach, WJ; Cramer, RA; Perfect, BZ; Henn, C; Nielsen, K; Heitman, J; Perfect, JR

Published Date

August 2007

Published In

Antimicrobial Agents and Chemotherapy

Volume / Issue

51 / 8

Start / End Page

2979 - 2981

PubMed ID

17502415

Pubmed Central ID

17502415

Electronic International Standard Serial Number (EISSN)

1098-6596

International Standard Serial Number (ISSN)

0066-4804

Digital Object Identifier (DOI)

10.1128/AAC.01394-06

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