Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.


Journal Article

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Full Text

Duke Authors

Cited Authors

  • Steinbach, WJ; Cramer, RA; Perfect, BZ; Henn, C; Nielsen, K; Heitman, J; Perfect, JR

Published Date

  • August 2007

Published In

Volume / Issue

  • 51 / 8

Start / End Page

  • 2979 - 2981

PubMed ID

  • 17502415

Pubmed Central ID

  • 17502415

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.01394-06


  • eng

Conference Location

  • United States