Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.


Journal Article

Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.

Full Text

Duke Authors

Cited Authors

  • Fortwendel, JR; Juvvadi, PR; Rogg, LE; Steinbach, WJ

Published Date

  • April 2011

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 611 - 615

PubMed ID

  • 21278230

Pubmed Central ID

  • 21278230

Electronic International Standard Serial Number (EISSN)

  • 1535-9786

Digital Object Identifier (DOI)

  • 10.1128/EC.00315-10


  • eng

Conference Location

  • United States