The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Journal Article (Journal Article)

The Aspergillus fumigatus DeltapmrA (Golgi apparatus Ca(2+)/Mn(2+) P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.

Full Text

Duke Authors

Cited Authors

  • Pinchai, N; Juvvadi, PR; Fortwendel, JR; Perfect, BZ; Rogg, LE; Asfaw, YG; Steinbach, WJ

Published Date

  • March 2010

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 472 - 476

PubMed ID

  • 20097742

Pubmed Central ID

  • PMC2837981

Electronic International Standard Serial Number (EISSN)

  • 1535-9786

Digital Object Identifier (DOI)

  • 10.1128/EC.00378-09


  • eng

Conference Location

  • United States