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Aquatic models, genomics and chemical risk management.

Publication ,  Journal Article
Cheng, KC; Hinton, DE; Mattingly, CJ; Planchart, A
Published in: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
January 2012

The 5th Aquatic Animal Models for Human Disease meeting follows four previous meetings (Nairn et al., 2001; Schmale, 2004; Schmale et al., 2007; Hinton et al., 2009) in which advances in aquatic animal models for human disease research were reported, and community discussion of future direction was pursued. At this meeting, discussion at a workshop entitled Bioinformatics and Computational Biology with Web-based Resources (20 September 2010) led to an important conclusion: Aquatic model research using feral and experimental fish, in combination with web-based access to annotated anatomical atlases and toxicological databases, yields data that advance our understanding of human gene function, and can be used to facilitate environmental management and drug development. We propose here that the effects of genes and environment are best appreciated within an anatomical context - the specifically affected cells and organs in the whole animal. We envision the use of automated, whole-animal imaging at cellular resolution and computational morphometry facilitated by high-performance computing and automated entry into toxicological databases, as anchors for genetic and toxicological data, and as connectors between human and model system data. These principles should be applied to both laboratory and feral fish populations, which have been virtually irreplaceable sentinals for environmental contamination that results in human morbidity and mortality. We conclude that automation, database generation, and web-based accessibility, facilitated by genomic/transcriptomic data and high-performance and cloud computing, will potentiate the unique and potentially key roles that aquatic models play in advancing systems biology, drug development, and environmental risk management.

Duke Scholars

Published In

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

DOI

ISSN

1532-0456

Publication Date

January 2012

Volume

155

Issue

1

Start / End Page

169 / 173

Related Subject Headings

  • User-Computer Interface
  • Toxicology
  • Risk Factors
  • Models, Animal
  • Internet
  • Genomics
  • Gene-Environment Interaction
  • Fishes
  • Environmental Monitoring
  • Environmental Exposure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cheng, K. C., Hinton, D. E., Mattingly, C. J., & Planchart, A. (2012). Aquatic models, genomics and chemical risk management. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 155(1), 169–173. https://doi.org/10.1016/j.cbpc.2011.06.009
Cheng, Keith C., David E. Hinton, Carolyn J. Mattingly, and Antonio Planchart. “Aquatic models, genomics and chemical risk management.Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP 155, no. 1 (January 2012): 169–73. https://doi.org/10.1016/j.cbpc.2011.06.009.
Cheng KC, Hinton DE, Mattingly CJ, Planchart A. Aquatic models, genomics and chemical risk management. Comparative biochemistry and physiology Toxicology & pharmacology : CBP. 2012 Jan;155(1):169–73.
Cheng, Keith C., et al. “Aquatic models, genomics and chemical risk management.Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 155, no. 1, Jan. 2012, pp. 169–73. Epmc, doi:10.1016/j.cbpc.2011.06.009.
Cheng KC, Hinton DE, Mattingly CJ, Planchart A. Aquatic models, genomics and chemical risk management. Comparative biochemistry and physiology Toxicology & pharmacology : CBP. 2012 Jan;155(1):169–173.
Journal cover image

Published In

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

DOI

ISSN

1532-0456

Publication Date

January 2012

Volume

155

Issue

1

Start / End Page

169 / 173

Related Subject Headings

  • User-Computer Interface
  • Toxicology
  • Risk Factors
  • Models, Animal
  • Internet
  • Genomics
  • Gene-Environment Interaction
  • Fishes
  • Environmental Monitoring
  • Environmental Exposure