Occurrence of subcortical hyperintensities in elderly subjects with mania.


Journal Article

In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities. Compared with controls, the patients demonstrated a significantly greater number of large subcortical hyperintensities, particularly in the middle third of the brain parenchyma. The lesions occurred with equal frequency in the right and left hemisphere. There were no differences between the two groups in the size of the ventricles or the presence of periventricular hyperintensities.

Full Text

Duke Authors

Cited Authors

  • McDonald, WM; Krishnan, KR; Doraiswamy, PM; Blazer, DG

Published Date

  • December 1991

Published In

Volume / Issue

  • 40 / 4

Start / End Page

  • 211 - 220

PubMed ID

  • 1811239

Pubmed Central ID

  • 1811239

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0925-4927(91)90013-g


  • eng

Conference Location

  • Ireland