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Association of interleukin-6 and other biologic variables with depression in older people living in the community.

Publication ,  Journal Article
Dentino, AN; Pieper, CF; Rao, MK; Currie, MS; Harris, T; Blazer, DG; Cohen, HJ
Published in: J Am Geriatr Soc
January 1999

OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin-6 (IL-6). This analysis was performed to determine the association between increased levels of this cytokine and depression in a population-based sample. DESIGN: Cross-sectional cohort study. SETTING: Rural and urban counties in North Carolina. PARTICIPANTS: Community-dwelling older people. MEASUREMENTS: The association between IL-6 and other biologic variables with self-report depression was examined in 1686 persons aged 70 years and older in the third in-person survey wave (1991) of the Duke Established Population for Epidemiologic Studies of the Elderly (EPESE). Bivariate associations were established by the Spearman correlation, adjusted for age. A stepwise linear logistic regression model was used to derive a final model to assess multivariable effects on CES-D scores. RESULTS: Depression was correlated with IL-6 (P = .011), D-Dimer (P = .017), alpha-1-globulin (P = .023), alpha-2-globulin (P = .002), and beta globulin (P = .012). After controlling for age, race, and gender, IL-6 levels remained the only biologic variable significantly associated with depression (P = .035). CONCLUSION: These data suggest that the inflammatory marker, IL-6, is associated with depression in older people in this cross-sectional study. These results are compatible with the hypothesis of cytokine (IL-6) stimulation in geriatric depression as part of an overall immunoendocrine dysregulation.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

January 1999

Volume

47

Issue

1

Start / End Page

6 / 11

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Prevalence
  • North Carolina
  • Male
  • Linear Models
  • Interleukin-6
  • Humans
  • Health Surveys
  • Geriatrics
  • Follow-Up Studies
 

Citation

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MLA
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Dentino, A. N., Pieper, C. F., Rao, M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J. (1999). Association of interleukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc, 47(1), 6–11. https://doi.org/10.1111/j.1532-5415.1999.tb01894.x
Dentino, A. N., C. F. Pieper, M. K. Rao, M. S. Currie, T. Harris, D. G. Blazer, and H. J. Cohen. “Association of interleukin-6 and other biologic variables with depression in older people living in the community.J Am Geriatr Soc 47, no. 1 (January 1999): 6–11. https://doi.org/10.1111/j.1532-5415.1999.tb01894.x.
Dentino AN, Pieper CF, Rao MK, Currie MS, Harris T, Blazer DG, et al. Association of interleukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc. 1999 Jan;47(1):6–11.
Dentino, A. N., et al. “Association of interleukin-6 and other biologic variables with depression in older people living in the community.J Am Geriatr Soc, vol. 47, no. 1, Jan. 1999, pp. 6–11. Pubmed, doi:10.1111/j.1532-5415.1999.tb01894.x.
Dentino AN, Pieper CF, Rao MK, Currie MS, Harris T, Blazer DG, Cohen HJ. Association of interleukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc. 1999 Jan;47(1):6–11.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

January 1999

Volume

47

Issue

1

Start / End Page

6 / 11

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Prevalence
  • North Carolina
  • Male
  • Linear Models
  • Interleukin-6
  • Humans
  • Health Surveys
  • Geriatrics
  • Follow-Up Studies