Six-month outcomes for MRI-related vascular depression.

Journal Article (Journal Article)

The purpose of this paper is to estimate the relative probabilities of 6-month recovery from an index episode of major depression for subjects with and without MRI-confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke University Mental Health Clinical Research Center (MHCRC) for Depression in Late Life who presented with MRI-related vascular and non-vascular depression were followed for 6 months, and the rates of recovery in the two risk groups were compared. Overall, the recovery rate in this sample was 57.9%. Subjects with MRI-related vascular depression demonstrated outcomes similar to subjects with non-vascular depression (crude RR = 0.67 [0.32, 1.43]). There was a trend that demonstrated that MRI-related vascular depression placed elderly subjects and subjects with first onset of depression after age 40 at increased risk of non-recovery. The study demonstrates overall no significant difference in course between patients with and without vascular depression. It also suggests that patients with vascular depression may have a different course depending on their age and age of onset of the disease.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Hays, JC; George, LK; Blazer, DG

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 142 - 146

PubMed ID

  • 9871815

International Standard Serial Number (ISSN)

  • 1091-4269

Digital Object Identifier (DOI)

  • 10.1002/(sici)1520-6394(1998)8:4<142::aid-da2>;2-n


  • eng

Conference Location

  • United States