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Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.

Publication ,  Journal Article
Blazer, DG; Malmrose, LC; Wallsten, SM; Nemeroff, CB; Reed, DA; Ritchie, JC; Tyrey, ME
Published in: Neurobiol Aging
1993

Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine daily rhythms in activity levels, mood, alertness, and performance. Seven healthy subjects were given a cumulative activity score reflecting propensity toward morningness or eveningness. Subjects underwent CRH challenge testing during the morning and evening hours of different days. Baseline plasma ACTH and cortisol concentrations were higher in the morning than in the evening and lower values were associated with lower activity scores (i.e., greater morningness). No trends were apparent between activity score and net hormone response or percent change in hormone concentration.

Duke Scholars

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1993

Volume

14

Issue

1

Start / End Page

101 / 106

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Sex Characteristics
  • Neurology & Neurosurgery
  • Motor Activity
  • Male
  • Hydrocortisone
  • Humans
  • Female
  • Corticotropin-Releasing Hormone
  • Circadian Rhythm
 

Citation

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Blazer, D. G., Malmrose, L. C., Wallsten, S. M., Nemeroff, C. B., Reed, D. A., Ritchie, J. C., & Tyrey, M. E. (1993). Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects. Neurobiol Aging, 14(1), 101–106. https://doi.org/10.1016/0197-4580(93)90029-b
Blazer, D. G., L. C. Malmrose, S. M. Wallsten, C. B. Nemeroff, D. A. Reed, J. C. Ritchie, and M. E. Tyrey. “Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.Neurobiol Aging 14, no. 1 (1993): 101–6. https://doi.org/10.1016/0197-4580(93)90029-b.
Blazer DG, Malmrose LC, Wallsten SM, Nemeroff CB, Reed DA, Ritchie JC, et al. Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects. Neurobiol Aging. 1993;14(1):101–6.
Blazer, D. G., et al. “Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.Neurobiol Aging, vol. 14, no. 1, 1993, pp. 101–06. Pubmed, doi:10.1016/0197-4580(93)90029-b.
Blazer DG, Malmrose LC, Wallsten SM, Nemeroff CB, Reed DA, Ritchie JC, Tyrey ME. Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects. Neurobiol Aging. 1993;14(1):101–106.
Journal cover image

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1993

Volume

14

Issue

1

Start / End Page

101 / 106

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Sex Characteristics
  • Neurology & Neurosurgery
  • Motor Activity
  • Male
  • Hydrocortisone
  • Humans
  • Female
  • Corticotropin-Releasing Hormone
  • Circadian Rhythm