Antiangiogenic gene therapy of cancer: recent developments.

Published online

Journal Article

With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attention but strategies for their optimal use are still being developed. Gene therapy represents an attractive alternative to recombinant protein administration for several reasons. This review evaluates the potential advantages of gene transfer for antiangiogenic cancer therapy and describes preclinical gene transfer work with endogenous angiogenesis inhibitors demonstrating the feasibility of effectively suppressing and even eradicating tumors in animal models. Additionally, we describe the advantages and disadvantages of currently available gene transfer vectors and update novel developments in this field. In conclusion, gene therapy holds great promise in advancing antiangiogenesis as an effective cancer therapy and will undoubtedly be evaluated in human clinical trials in the near future.

Full Text

Duke Authors

Cited Authors

  • Tandle, A; Blazer, DG; Libutti, SK

Published Date

  • June 25, 2004

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 22 -

PubMed ID

  • 15219236

Pubmed Central ID

  • 15219236

Electronic International Standard Serial Number (EISSN)

  • 1479-5876

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-2-22


  • eng

Conference Location

  • England