Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.

Published

Journal Article

We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclusive groups were identified: primary cocaine users (n = 287), primary amphetamine users (n = 99), and dual users (cocaine and amphetamines; n = 29). Distinct subtypes were examined with latent class and logistic regression procedures. Cocaine users were distinct from amphetamine users in age and race/ethnicity. There were four distinct classes of primary cocaine users: non-dependence (15%), compulsive use (14%), tolerance and compulsive use (15%), and physiological dependence (tolerance, withdrawal, and compulsive use; 56%). Three distinct classes of primary amphetamine users were identified: non-dependence (11%), intermediate physiological dependence (31%), and physiological dependence (58%). Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V.

Full Text

Duke Authors

Cited Authors

  • Wu, L-T; Blazer, DG; Patkar, AA; Stitzer, ML; Wakim, PG; Brooner, RK

Published Date

  • May 2009

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 206 - 218

PubMed ID

  • 19340639

Pubmed Central ID

  • 19340639

Electronic International Standard Serial Number (EISSN)

  • 1521-0391

International Standard Serial Number (ISSN)

  • 1055-0496

Digital Object Identifier (DOI)

  • 10.1080/10550490902787031

Language

  • eng