Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.

Published

Journal Article

Vision in dim light requires that photons absorbed by rod photoreceptors evoke signals that reliably propagate through the retina. We investigated how a perturbation in rod physiology affects propagation of those signals in the retina and ultimately visual sensitivity. Recoverin is a protein in rods that prolongs phototransduction and enhances visual sensitivity. It is not present in neurons postsynaptic to rods, yet we found that light-evoked responses of rod bipolar and ganglion cells were shortened when measured in recoverin-deficient retinas. Unexpectedly, the effect of recoverin on postsynaptic signals could not be explained by its effect on phototransduction. Instead, it is an effect of recoverin downstream of phototransduction in rods that prolongs signal transmission and enhances visual sensitivity. An important implication of our findings is that the recovery phase of the rod photoresponse does not contribute significantly to visual sensitivity near absolute threshold.

Full Text

Duke Authors

Cited Authors

  • Sampath, AP; Strissel, KJ; Elias, R; Arshavsky, VY; McGinnis, JF; Chen, J; Kawamura, S; Rieke, F; Hurley, JB

Published Date

  • May 5, 2005

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 413 - 420

PubMed ID

  • 15882641

Pubmed Central ID

  • 15882641

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2005.04.006

Language

  • eng

Conference Location

  • United States