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Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.

Publication ,  Journal Article
Sampath, AP; Strissel, KJ; Elias, R; Arshavsky, VY; McGinnis, JF; Chen, J; Kawamura, S; Rieke, F; Hurley, JB
Published in: Neuron
May 5, 2005

Vision in dim light requires that photons absorbed by rod photoreceptors evoke signals that reliably propagate through the retina. We investigated how a perturbation in rod physiology affects propagation of those signals in the retina and ultimately visual sensitivity. Recoverin is a protein in rods that prolongs phototransduction and enhances visual sensitivity. It is not present in neurons postsynaptic to rods, yet we found that light-evoked responses of rod bipolar and ganglion cells were shortened when measured in recoverin-deficient retinas. Unexpectedly, the effect of recoverin on postsynaptic signals could not be explained by its effect on phototransduction. Instead, it is an effect of recoverin downstream of phototransduction in rods that prolongs signal transmission and enhances visual sensitivity. An important implication of our findings is that the recovery phase of the rod photoresponse does not contribute significantly to visual sensitivity near absolute threshold.

Duke Scholars

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

May 5, 2005

Volume

46

Issue

3

Start / End Page

413 / 420

Location

United States

Related Subject Headings

  • Vision, Ocular
  • Retinal Rod Photoreceptor Cells
  • Recoverin
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Lipoproteins
  • Immunoblotting
  • Fluorescent Antibody Technique
  • Eye Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sampath, A. P., Strissel, K. J., Elias, R., Arshavsky, V. Y., McGinnis, J. F., Chen, J., … Hurley, J. B. (2005). Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina. Neuron, 46(3), 413–420. https://doi.org/10.1016/j.neuron.2005.04.006
Sampath, Alapakkam P., Katherine J. Strissel, Rajesh Elias, Vadim Y. Arshavsky, James F. McGinnis, Jeannie Chen, Satoru Kawamura, Fred Rieke, and James B. Hurley. “Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.Neuron 46, no. 3 (May 5, 2005): 413–20. https://doi.org/10.1016/j.neuron.2005.04.006.
Sampath AP, Strissel KJ, Elias R, Arshavsky VY, McGinnis JF, Chen J, et al. Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina. Neuron. 2005 May 5;46(3):413–20.
Sampath, Alapakkam P., et al. “Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.Neuron, vol. 46, no. 3, May 2005, pp. 413–20. Pubmed, doi:10.1016/j.neuron.2005.04.006.
Sampath AP, Strissel KJ, Elias R, Arshavsky VY, McGinnis JF, Chen J, Kawamura S, Rieke F, Hurley JB. Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina. Neuron. 2005 May 5;46(3):413–420.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

May 5, 2005

Volume

46

Issue

3

Start / End Page

413 / 420

Location

United States

Related Subject Headings

  • Vision, Ocular
  • Retinal Rod Photoreceptor Cells
  • Recoverin
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Lipoproteins
  • Immunoblotting
  • Fluorescent Antibody Technique
  • Eye Proteins