G proteins and phototransduction.


Journal Article (Review)

Phototransduction is the process by which a photon of light captured by a molecule of visual pigment generates an electrical response in a photoreceptor cell. Vertebrate rod phototransduction is one of the best-studied G protein signaling pathways. In this pathway the photoreceptor-specific G protein, transducin, mediates between the visual pigment, rhodopsin, and the effector enzyme, cGMP phosphodiesterase. This review focuses on two quantitative features of G protein signaling in phototransduction: signal amplification and response timing. We examine how the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light.

Full Text

Duke Authors

Cited Authors

  • Arshavsky, VY; Lamb, TD; Pugh, EN

Published Date

  • 2002

Published In

Volume / Issue

  • 64 /

Start / End Page

  • 153 - 187

PubMed ID

  • 11826267

Pubmed Central ID

  • 11826267

International Standard Serial Number (ISSN)

  • 0066-4278

Digital Object Identifier (DOI)

  • 10.1146/annurev.physiol.64.082701.102229


  • eng

Conference Location

  • United States