New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.

Journal Article (Journal Article)

A series of ethacrynic acid (ECA) derivatives were synthesized and examined for ocular hypotensive activity. Efficacy was evaluated in a cell-shape assay, using human trabecular meshwork cells, and cytotoxicity in a (3-(4,5-dimethylthiazole-2-yl)-5-(3-carboxymethoxy phenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay, using cultured bovine trabecular meshwork cells. Many of the derivatives demonstrated efficacy equal to or greater than that of ECA. SA9000 was selected as the most promising candidate for a novel ocular hypotensive drug with few side effects.

Full Text

Duke Authors

Cited Authors

  • Shimazaki, A; Suhara, H; Ichikawa, M; Matsugi, T; Konomi, K; Takagi, Y; Hara, H; Rao, PV; Epstein, DL

Published Date

  • June 2004

Published In

Volume / Issue

  • 27 / 6

Start / End Page

  • 846 - 850

PubMed ID

  • 15187431

International Standard Serial Number (ISSN)

  • 0918-6158

Digital Object Identifier (DOI)

  • 10.1248/bpb.27.846

Language

  • eng

Conference Location

  • Japan