New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.
Journal Article
A series of ethacrynic acid (ECA) derivatives were synthesized and examined for ocular hypotensive activity. Efficacy was evaluated in a cell-shape assay, using human trabecular meshwork cells, and cytotoxicity in a (3-(4,5-dimethylthiazole-2-yl)-5-(3-carboxymethoxy phenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay, using cultured bovine trabecular meshwork cells. Many of the derivatives demonstrated efficacy equal to or greater than that of ECA. SA9000 was selected as the most promising candidate for a novel ocular hypotensive drug with few side effects.
Full Text
Duke Authors
Cited Authors
- Shimazaki, A; Suhara, H; Ichikawa, M; Matsugi, T; Konomi, K; Takagi, Y; Hara, H; Rao, PV; Epstein, DL
Published Date
- June 2004
Published In
Volume / Issue
- 27 / 6
Start / End Page
- 846 - 850
PubMed ID
- 15187431
Pubmed Central ID
- 15187431
International Standard Serial Number (ISSN)
- 0918-6158
Digital Object Identifier (DOI)
- 10.1248/bpb.27.846
Language
- eng
Conference Location
- Japan