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Cellular senescence in the glaucomatous outflow pathway.

Publication ,  Journal Article
Liton, PB; Challa, P; Stinnett, S; Luna, C; Epstein, DL; Gonzalez, P
Published in: Exp Gerontol
2005

The mechanisms responsible for the progressive malfunction of the trabecular meshwork (TM)-Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle glaucoma (POAG) are still not fully understood. To determine whether POAG is characterized by an accumulation of senescent cells, similar to what has been described in other diseases, we have compared the levels of the senescence marker senescence-associated-beta-galactosidase (SA-beta-gal) in the outflow pathway cells of POAG and age-matched control donors. POAG donors demonstrated a statistically significant fourfold increase in the percentage of SA-beta-gal positive cells. These results suggest a potential role for cellular senescence in the pathophysiology of the outflow pathway.

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Published In

Exp Gerontol

DOI

ISSN

0531-5565

Publication Date

2005

Volume

40

Issue

8-9

Start / End Page

745 / 748

Location

England

Related Subject Headings

  • beta-Galactosidase
  • Vitreous Body
  • Statistics, Nonparametric
  • Staining and Labeling
  • Sclera
  • Microscopy, Fluorescence
  • Humans
  • Glaucoma, Open-Angle
  • Gerontology
  • Eye
 

Citation

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Liton, P. B., Challa, P., Stinnett, S., Luna, C., Epstein, D. L., & Gonzalez, P. (2005). Cellular senescence in the glaucomatous outflow pathway. Exp Gerontol, 40(8–9), 745–748. https://doi.org/10.1016/j.exger.2005.06.005
Liton, Paloma B., Pratap Challa, Sandra Stinnett, Coralia Luna, David L. Epstein, and Pedro Gonzalez. “Cellular senescence in the glaucomatous outflow pathway.Exp Gerontol 40, no. 8–9 (2005): 745–48. https://doi.org/10.1016/j.exger.2005.06.005.
Liton PB, Challa P, Stinnett S, Luna C, Epstein DL, Gonzalez P. Cellular senescence in the glaucomatous outflow pathway. Exp Gerontol. 2005;40(8–9):745–8.
Liton, Paloma B., et al. “Cellular senescence in the glaucomatous outflow pathway.Exp Gerontol, vol. 40, no. 8–9, 2005, pp. 745–48. Pubmed, doi:10.1016/j.exger.2005.06.005.
Liton PB, Challa P, Stinnett S, Luna C, Epstein DL, Gonzalez P. Cellular senescence in the glaucomatous outflow pathway. Exp Gerontol. 2005;40(8–9):745–748.
Journal cover image

Published In

Exp Gerontol

DOI

ISSN

0531-5565

Publication Date

2005

Volume

40

Issue

8-9

Start / End Page

745 / 748

Location

England

Related Subject Headings

  • beta-Galactosidase
  • Vitreous Body
  • Statistics, Nonparametric
  • Staining and Labeling
  • Sclera
  • Microscopy, Fluorescence
  • Humans
  • Glaucoma, Open-Angle
  • Gerontology
  • Eye