Cellular senescence in the glaucomatous outflow pathway.

Journal Article (Journal Article)

The mechanisms responsible for the progressive malfunction of the trabecular meshwork (TM)-Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle glaucoma (POAG) are still not fully understood. To determine whether POAG is characterized by an accumulation of senescent cells, similar to what has been described in other diseases, we have compared the levels of the senescence marker senescence-associated-beta-galactosidase (SA-beta-gal) in the outflow pathway cells of POAG and age-matched control donors. POAG donors demonstrated a statistically significant fourfold increase in the percentage of SA-beta-gal positive cells. These results suggest a potential role for cellular senescence in the pathophysiology of the outflow pathway.

Full Text

Duke Authors

Cited Authors

  • Liton, PB; Challa, P; Stinnett, S; Luna, C; Epstein, DL; Gonzalez, P

Published Date

  • 2005

Published In

Volume / Issue

  • 40 / 8-9

Start / End Page

  • 745 - 748

PubMed ID

  • 16051457

Pubmed Central ID

  • PMC3152456

International Standard Serial Number (ISSN)

  • 0531-5565

Digital Object Identifier (DOI)

  • 10.1016/j.exger.2005.06.005


  • eng

Conference Location

  • England