Light-driven translocation of signaling proteins in vertebrate photoreceptors.

Published

Journal Article (Review)

The dynamic localization of proteins within cells is often determined by environmental stimuli. In retinal photoreceptors, light exposure results in the massive translocation of three key signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment where phototransduction takes place. This phenomenon has rapidly taken the center stage of photoreceptor cell biology, thanks to the introduction of new quantitative and transgenic approaches. Here, we discuss evidence that intracellular protein translocation contributes to adaptation of photoreceptors to diurnal changes in ambient light intensity and summarize the current debate on whether it is driven by diffusion or molecular motors.

Full Text

Duke Authors

Cited Authors

  • Calvert, PD; Strissel, KJ; Schiesser, WE; Pugh, EN; Arshavsky, VY

Published Date

  • November 2006

Published In

Volume / Issue

  • 16 / 11

Start / End Page

  • 560 - 568

PubMed ID

  • 16996267

Pubmed Central ID

  • 16996267

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2006.09.001

Language

  • eng

Conference Location

  • England