Cataractogenic effects of a boron hydride disulfide compound.


Journal Article

The disulfide form but not the sulfhydryl form of a boron hydride compound was found to be cataractogenic. Apparently this compound attaches to the sulfhydryl group of Na-K ATPase in the lens epithelium inactivating this crucial enzyme. The consequence is that a defect in the cation pump activity arises, leading to a rapid influx of Na ions and loss of K ions and marked increase in hydration. These changes are thought to lead to opacification.

Full Text

Cited Authors

  • Fukui, HN; Iwata, S; Epstein, DL; Merola, LO

Published Date

  • July 1, 1977

Published In

Volume / Issue

  • 16 / 7

Start / End Page

  • 654 - 657

PubMed ID

  • 141427

Pubmed Central ID

  • 141427

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 0146-0404


  • eng