Influence of mercurial sulfhydryl agents on aqueous outflow pathways in enucleated eyes.


Journal Article

Enucleated calf and primate eyes were perfused with either p-chloromercuribenzene sulfonate (PCMBS) or p-chloromercuribenzene (PCMB). Both caused a decrease in aqueous outflow that did not result from inhibition of glycolysis in trabecular cells. Morphologic studies of PCMBS-treated primate eyes suggested that the reduction in aqueous outflow occurred as the result of cellular swelling in the trabecular meshwork and, particularly, in the juxtacanalicular connective tissue. These findings suggest that changes in cell volume may influence trabecular outflow resistance and that mercurial-sensitive membrane sulfhydryl groups could participate in the regulation of aqueous outflow.

Full Text

Cited Authors

  • Freddo, TF; Patterson, MM; Scott, DR; Epstein, DL

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 25 / 3

Start / End Page

  • 278 - 285

PubMed ID

  • 6321388

Pubmed Central ID

  • 6321388

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 0146-0404


  • eng