Q-switched neodymium-YAG laser trabeculopuncture in monkeys.

Published

Journal Article

In nine cynomolgus monkeys, trabeculopuncture was performed with a Q-switched neodymium-YAG laser, using a pulse energy of 5 to 7 millijoules and an exposure time of 14 nanoseconds. A penetration into Schlemm's canal was successfully achieved with two to four pulses; this penetration was accompanied by intraocular pressure (IOP) reduction and blood reflux into the anterior chamber. However, after eight days, IOP returned to baseline level, while white tissue was observed gonioscopically to fill in the puncture sites. Histologically, one hour after laser treatment, a blasting effect on the trabecular meshwork was observed with no signs of necrosis. Ater eight days, a hypertrophic scar formed, with the corneal endothelium extending over the scarred surface. At eight weeks and at six months after laser treatment, further shrinkage of the scar and the formation of a membrane over it was evident. Attempts to control scar formation by preventing blood reflux or injecting fluorouracil subconjunctivally for two weeks were unsuccessful. Scar formation at the trabecular puncture site severely limits the applicability of this potentially simple glaucoma treatment.

Full Text

Cited Authors

  • Melamed, S; Pei, J; Puliafito, CA; Epstein, DL

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 103 / 1

Start / End Page

  • 129 - 133

PubMed ID

  • 3977666

Pubmed Central ID

  • 3977666

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.1985.01050010135037

Language

  • eng