Obstruction of aqueous outflow by lens particles and by heavy-molecular-weight soluble lens proteins.


Journal Article

Enucleated human eyes were perfused via the anterior chamber at 25 mm Hg pressure with lens particles (whole lens homogenates) in one series of experiments and with soluble lens proteins from human cataractous lenses in another series. Adding 1% of a homogenate of a single cataractous lens to the anterior chamber induced a 68% decrease in outflow. Perfusion with HMW soluble lens proteins (1 mg/ml; MW more than 150 million) caused a 60% decrease in outflow in 1 hr. In neither series was the obstruction to outflow relieved by subsequent irrigation of the anterior chamber with balanced salt solution or alpha-chymotrypsin. The results show that both lens particles and soluble lens proteins can directly obstruct the aqueous outflow pathways of human eyes. Such obstruction may be a significant factor in certain lens-induced glaucomas.

Full Text

Cited Authors

  • Epstein, DL; Jedziniak, JA; Grant, WM

Published Date

  • March 1, 1978

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 272 - 277

PubMed ID

  • 627464

Pubmed Central ID

  • 627464

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 0146-0404


  • eng