Effect of delta 9-tetrahydrocannabinol on monoamine oxidase activity in bovine eye tissues, in vitro.


Journal Article

An investigation was undertaken to analyze the effects of delta 9-tetrahydrocannabinol (THC) on monoamine oxidase (MAO) activity from calf ocular tissues. Ciliary processes, retina, trabecular meshwork, choroid, and iris all demonstrated significant MAO activity in decreasing order of magnitude. THC in concentrations from 10(-8)M to 10(-12)M stimulated MAO activity in extracts from all five tissues, except for iris at 10(-8)M. Maximum stimulation of MAO activity occurred at the 1 x 10(-12)M level for all tissues. Retina, followed next by trabecular meshwork and then ciliary processes, exhibited the largest increase in MAO activity at 10(-12)M THC. This latter effect could possibly by related to the influence of THC on intraocular pressure.

Full Text

Cited Authors

  • Gawienowski, AM; Chatterjee, D; Anderson, PJ; Epstein, DL; Grant, WM

Published Date

  • April 1982

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 482 - 485

PubMed ID

  • 6277821

Pubmed Central ID

  • 6277821

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 0146-0404


  • eng