Short-term effect of argon laser trabeculoplasty in monkeys.


Journal Article

We performed argon laser trabeculoplasty (ALT) in four cynomolgus monkeys and evaluated the morphologic changes in the trabecular meshwork one hour and 14 hours following the laser treatment. One hour after ALT, disruption of the trabecular beams and coagulative necrosis of the tissue were evident. Fragmented cells and fibrillar tissue debris were found in the trabecular spaces, accumulating in the juxtacanalicular region. This might explain the elevation of intraocular pressure seen immediately following ALT in some glaucomatous patients. Also, many trabecular endothelial cells were rounded up, displaying different stages of leaving the beams; these cells were actively phagocytic. Such stimulation of trabecular meshwork cells with subsequent removal of tissue debris might explain the temporary nature of elevation of intraocular pressure following ALT.

Full Text

Cited Authors

  • Melamed, S; Pei, J; Epstein, DL

Published Date

  • October 1, 1985

Published In

Volume / Issue

  • 103 / 10

Start / End Page

  • 1546 - 1552

PubMed ID

  • 4051857

Pubmed Central ID

  • 4051857

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.1985.01050100122032


  • eng