MK-507 versus sezolamide. Comparative efficacy of two topically active carbonic anhydrase inhibitors.
Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours, or placebo every 8 or 12 hours for 4 days. Both drugs lowered intraocular pressure (IOP) substantially. MK-507 was somewhat more active than sezolamide, with a peak mean IOP reduction of 26.2% for MK-507 versus 22.5% for sezolamide, although the difference between the treatments was not statistically significant. These drugs may have potential in the treatment of glaucoma.
Lippa, EA; Schuman, JS; Higginbotham, EJ; Kass, MA; Weinreb, RN; Skuta, GL; Epstein, DL; Shaw, B; Holder, DJ; Deasy, DA
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