Experimental ab interno sclerotomies using a pulsed-dye laser.

Published

Journal Article

We studied the use of a short-pulse, flashlamp-pumped dye laser, emitting at 666 nm, to create ab interno sclerotomies in cynomolgus monkeys using a fiberoptic delivery system. Because of the low optical absorption of the sclera in the visible portion of the spectrum, ablation of sclera by continuous wave lasers emitting in this region requires high energies and produces significant thermal damage to surrounding tissues. To enhance the optical absorption of sclera, methylene blue dye was applied iontophoretically; patent sclerotomies were obtained in all 10 eyes of six cynomolgus monkeys, with energies ranging from 15 to 50 mj/pulse. Thermal damage to the adjacent sclera was confined to 300 microns. Complications included mild intraoperative hyphema at all pulse energies and iridodialysis at higher pulse energies. Filtration blebs routinely failed within 7 days; the use of 5-fluorouracil postoperatively significantly prolonged bleb duration. The small incision technique described allows ab interno sclerotomies to be created with low pulse energies without the need for conjunctival dissection, thereby avoiding the problems associated with conjunctival wounds. An advantage of this technique is that it can be modified to create ab interno sclerotomies noninvasively by delivering pulsed visible radiation through the cornea with a gonioscopic-slitlamp system.

Full Text

Cited Authors

  • Latina, M; Goode, S; de Kater, AW; Long, FH; Deutsch, TF; Epstein, DL

Published Date

  • January 1988

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 233 - 240

PubMed ID

  • 3393051

Pubmed Central ID

  • 3393051

Electronic International Standard Serial Number (EISSN)

  • 1096-9101

International Standard Serial Number (ISSN)

  • 0196-8092

Digital Object Identifier (DOI)

  • 10.1002/lsm.1900080303

Language

  • eng