Topical indomethacin therapy before argon laser trabeculoplasty.

Journal Article (Clinical Trial;Journal Article)

Fifty treatment sessions for 43 eyes (35 patients) receiving argon laser trabeculoplasty to one-half the angle were randomly assigned in a double-masked fashion to pretreatment with either topical indomethacin 1% or placebo. In 25 treatments intraocular pressure increased 3 mm Hg or more within four hours. Topical indomethacin pretreatment had no effect on the incidence, magnitude, or time course of this acute increase. It also did not alter the long-term effectiveness of the laser treatment (-3.8 mm Hg in the indomethacin-treated group vs -4.3 mm Hg in the placebo-treated group). The overall incidence of new peripheral anterior synechiae found on gonioscopy at one month was 32% (16 of 50 treatments). Synechiae formation was much higher in blacks (ten of 11 eyes or 91%) than in whites (five of 38 eyes or 13%). Although there was an association between acute anterior chamber inflammation after laser treatment and ultimate synechia formation (P less than .05), indomethacin pretreatment did not alter its occurrence.

Full Text

Duke Authors

Cited Authors

  • Pappas, HR; Berry, DP; Partamian, L; Hertzmark, E; Epstein, DL

Published Date

  • May 15, 1985

Published In

Volume / Issue

  • 99 / 5

Start / End Page

  • 571 - 575

PubMed ID

  • 4003494

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/s0002-9394(14)77961-9


  • eng

Conference Location

  • United States