Molecular genetics in glaucoma.

Published

Journal Article (Review)

Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle-closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to glaucoma phenotypes. This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma (PCG), the developmental glaucomas, and pigment dispersion glaucoma.

Full Text

Duke Authors

Cited Authors

  • Liu, Y; Allingham, RR

Published Date

  • October 2011

Published In

Volume / Issue

  • 93 / 4

Start / End Page

  • 331 - 339

PubMed ID

  • 21871452

Pubmed Central ID

  • 21871452

Electronic International Standard Serial Number (EISSN)

  • 1096-0007

Digital Object Identifier (DOI)

  • 10.1016/j.exer.2011.08.007

Language

  • eng

Conference Location

  • England