A method for determination of antibody-dependent cellular cytotoxicity (ADCC) of human peripheral mononuclear cells.


Journal Article

A method is described for measuring antibody-dependent cellular cytotoxicity (ADCC) of mononuclear cells from human peripheral blood using an established murine cell line and commercially prepared antisera. The test utilizes a standard 51Cr release technique. The ADCC activity of mononuclear cells obtained from 10 healthy human volunteers was measured at 4 different effector: target cell ratios. A linear relationship between %51Cr release (ADCC) and the number of effector cells was observed.

Full Text

Duke Authors

Cited Authors

  • Wisecarver, J; Bechtold, T; Collins, M; Davis, J; Lipscomb, H; Sonnabend, J; Purtilo, DT

Published Date

  • May 1, 1985

Published In

Volume / Issue

  • 79 / 2

Start / End Page

  • 277 - 282

PubMed ID

  • 3998480

Pubmed Central ID

  • 3998480

Electronic International Standard Serial Number (EISSN)

  • 1872-7905

International Standard Serial Number (ISSN)

  • 0022-1759

Digital Object Identifier (DOI)

  • 10.1016/0022-1759(85)90107-3


  • eng