Lymphocyte subsets in Chediak-Higashi patients.
Publication
, Journal Article
Merino, F; Lipscomb, H; Amesty, C; Purtilo, D; Ramírez-Duque, P
Published in: Immunol Lett
February 1983
Peripheral blood lymphocyte subsets were studied in 6 Chediak-Higashi patients and 12 family members. The lymphocyte subsets were characterized by monoclonal antibody reagents and fluorescence flow-cytometry. An increase in OKT8 (suppressor/cytotoxic) and a decrease in OKT4 (helper) cell populations was observed in all patients studied. No correlation was seen between the clinical status (presence or absence of the lymphoproliferative phase) and the percentage of the lymphocyte subsets. The patient's mothers also had an increased percentage of OKT8-positive cells. The significance of these findings is discussed regarding the patients clinical course.
Duke Scholars
Published In
Immunol Lett
DOI
ISSN
0165-2478
Publication Date
February 1983
Volume
6
Issue
2
Start / End Page
81 / 85
Location
Netherlands
Related Subject Headings
- T-Lymphocytes, Regulatory
- T-Lymphocytes, Helper-Inducer
- T-Lymphocytes, Cytotoxic
- Male
- Lymphocytes
- Killer Cells, Natural
- Infant
- Immunology
- Humans
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Merino, F., Lipscomb, H., Amesty, C., Purtilo, D., & Ramírez-Duque, P. (1983). Lymphocyte subsets in Chediak-Higashi patients. Immunol Lett, 6(2), 81–85. https://doi.org/10.1016/0165-2478(83)90085-8
Merino, F., H. Lipscomb, C. Amesty, D. Purtilo, and P. Ramírez-Duque. “Lymphocyte subsets in Chediak-Higashi patients.” Immunol Lett 6, no. 2 (February 1983): 81–85. https://doi.org/10.1016/0165-2478(83)90085-8.
Merino F, Lipscomb H, Amesty C, Purtilo D, Ramírez-Duque P. Lymphocyte subsets in Chediak-Higashi patients. Immunol Lett. 1983 Feb;6(2):81–5.
Merino, F., et al. “Lymphocyte subsets in Chediak-Higashi patients.” Immunol Lett, vol. 6, no. 2, Feb. 1983, pp. 81–85. Pubmed, doi:10.1016/0165-2478(83)90085-8.
Merino F, Lipscomb H, Amesty C, Purtilo D, Ramírez-Duque P. Lymphocyte subsets in Chediak-Higashi patients. Immunol Lett. 1983 Feb;6(2):81–85.
Published In
Immunol Lett
DOI
ISSN
0165-2478
Publication Date
February 1983
Volume
6
Issue
2
Start / End Page
81 / 85
Location
Netherlands
Related Subject Headings
- T-Lymphocytes, Regulatory
- T-Lymphocytes, Helper-Inducer
- T-Lymphocytes, Cytotoxic
- Male
- Lymphocytes
- Killer Cells, Natural
- Infant
- Immunology
- Humans
- Female