Lymphocyte subsets in Chediak-Higashi patients.

Journal Article (Journal Article)

Peripheral blood lymphocyte subsets were studied in 6 Chediak-Higashi patients and 12 family members. The lymphocyte subsets were characterized by monoclonal antibody reagents and fluorescence flow-cytometry. An increase in OKT8 (suppressor/cytotoxic) and a decrease in OKT4 (helper) cell populations was observed in all patients studied. No correlation was seen between the clinical status (presence or absence of the lymphoproliferative phase) and the percentage of the lymphocyte subsets. The patient's mothers also had an increased percentage of OKT8-positive cells. The significance of these findings is discussed regarding the patients clinical course.

Full Text

Duke Authors

Cited Authors

  • Merino, F; Lipscomb, H; Amesty, C; Purtilo, D; Ramírez-Duque, P

Published Date

  • February 1, 1983

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 81 - 85

PubMed ID

  • 6221995

International Standard Serial Number (ISSN)

  • 0165-2478

Digital Object Identifier (DOI)

  • 10.1016/0165-2478(83)90085-8


  • eng

Conference Location

  • Netherlands