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Peripartum management of two parturients with ornithine transcarbamylase deficiency.

Publication ,  Journal Article
Ituk, U; Constantinescu, OC; Allen, TK; Small, MJ; Habib, AS
Published in: Int J Obstet Anesth
January 2012

Ornithine transcarbamylase deficiency is a rare X-linked disorder in which female carriers are usually heterozygous for the ornithine transcarbamylase deficiency gene. In pregnancy it has been associated with altered mental status, seizures, coma and death, especially in the postpartum period. We report the management of labor and delivery in two parturients with known ornithine transcarbamylase deficiency. Both patients were maintained on arginine, citrulline and sodium phenylacetate therapy with restricted protein intake during pregnancy. Neuraxial techniques were used for pain relief in labor and anesthesia for operative delivery. A dextrose infusion provided caloric intake during labor and perioperatively.

Duke Scholars

Published In

Int J Obstet Anesth

DOI

EISSN

1532-3374

Publication Date

January 2012

Volume

21

Issue

1

Start / End Page

90 / 93

Location

Netherlands

Related Subject Headings

  • Urea
  • Pregnancy Complications
  • Pregnancy
  • Peripartum Period
  • Ornithine Carbamoyltransferase Deficiency Disease
  • Humans
  • Female
  • Anesthesiology
  • Anesthesia, Obstetrical
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ituk, U., Constantinescu, O. C., Allen, T. K., Small, M. J., & Habib, A. S. (2012). Peripartum management of two parturients with ornithine transcarbamylase deficiency. Int J Obstet Anesth, 21(1), 90–93. https://doi.org/10.1016/j.ijoa.2011.09.007
Ituk, U., O. C. Constantinescu, T. K. Allen, M. J. Small, and A. S. Habib. “Peripartum management of two parturients with ornithine transcarbamylase deficiency.Int J Obstet Anesth 21, no. 1 (January 2012): 90–93. https://doi.org/10.1016/j.ijoa.2011.09.007.
Ituk U, Constantinescu OC, Allen TK, Small MJ, Habib AS. Peripartum management of two parturients with ornithine transcarbamylase deficiency. Int J Obstet Anesth. 2012 Jan;21(1):90–3.
Ituk, U., et al. “Peripartum management of two parturients with ornithine transcarbamylase deficiency.Int J Obstet Anesth, vol. 21, no. 1, Jan. 2012, pp. 90–93. Pubmed, doi:10.1016/j.ijoa.2011.09.007.
Ituk U, Constantinescu OC, Allen TK, Small MJ, Habib AS. Peripartum management of two parturients with ornithine transcarbamylase deficiency. Int J Obstet Anesth. 2012 Jan;21(1):90–93.
Journal cover image

Published In

Int J Obstet Anesth

DOI

EISSN

1532-3374

Publication Date

January 2012

Volume

21

Issue

1

Start / End Page

90 / 93

Location

Netherlands

Related Subject Headings

  • Urea
  • Pregnancy Complications
  • Pregnancy
  • Peripartum Period
  • Ornithine Carbamoyltransferase Deficiency Disease
  • Humans
  • Female
  • Anesthesiology
  • Anesthesia, Obstetrical
  • Adult