Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.

Published

Journal Article

Because selected xenobiotic-metabolizing enzymes process pro-carcinogens that could initiate ovarian carcinogenesis, we hypothesized that single nucleotide polymorphisms (SNPs) in the genes encoding xenobiotic-metabolizing enzymes are associated with risk of ovarian cancer. Cases with invasive epithelial ovarian cancer (N = 1571 including 956 of serous sub-type) and controls (N = 2046) from three studies were genotyped at 11 SNPs in EPHX1, ADH4, ADH1A, NQO2, NAT2, GSTP1, CYP1A1, and NQO1, following an initial SNP screen in a subset of participants. Logistic regression analysis of genotypes obtained via Illumina GoldenGate and Sequenom iPlex technologies revealed the following age- and study-adjusted associations: EPHX1 rs1051740 with increased serous ovarian cancer risk [per-allele odds ratio (OR) 1.17, 95% confidence interval (95% CI) 1.04-1.32, P = 0.01), ADH4 r1042364 with decreased ovarian cancer risk (OR 0.90, 95% CI: 0.81-1.00, P = 0.05), and NQO1 rs291766 with increased ovarian cancer risk (OR 1.11, 95% CI: 1.00-1.23, P = 0.04). These findings are consistent with prior studies implicating these genes in carcinogenesis and suggest that this collection of variants is worthy of follow-up in additional studies.

Full Text

Duke Authors

Cited Authors

  • Goode, EL; White, KL; Vierkant, RA; Phelan, CM; Cunningham, JM; Schildkraut, JM; Berchuck, A; Larson, MC; Fridley, BL; Olson, JE; Webb, PM; Chen, X; Beesley, J; Chenevix-Trench, G; Sellers, TA; Ovarian Cancer Association Consortium, ; Australian Ovarian Cancer Study Group,

Published Date

  • May 2011

Published In

Volume / Issue

  • 50 / 5

Start / End Page

  • 397 - 402

PubMed ID

  • 21480392

Pubmed Central ID

  • 21480392

Electronic International Standard Serial Number (EISSN)

  • 1098-2744

Digital Object Identifier (DOI)

  • 10.1002/mc.20714

Language

  • eng

Conference Location

  • United States