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Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Publication ,  Journal Article
Near, AM; Wu, AH; Templeman, C; Van Den Berg, DJ; Doherty, JA; Rossing, MA; Goode, EL; Cunningham, JM; Vierkant, RA; Fridley, BL; Webb, PM ...
Published in: Fertil Steril
January 2011

OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. SETTING: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. PATIENT(S): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. RESULT(S): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio=0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio=0.94, 95% confidence interval 0.76-1.16). CONCLUSION(S): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

Duke Scholars

Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

January 2011

Volume

95

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Receptors, Progesterone
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • International Cooperation
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Near, A. M., Wu, A. H., Templeman, C., Van Den Berg, D. J., Doherty, J. A., Rossing, M. A., … Australian Ovarian Cancer Study Group (AOCS), . (2011). Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort. Fertil Steril, 95(1), 40–45. https://doi.org/10.1016/j.fertnstert.2010.06.059
Near, Aimee M., Anna H. Wu, Claire Templeman, David J. Van Den Berg, Jennifer A. Doherty, Mary Anne Rossing, Ellen L. Goode, et al. “Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.Fertil Steril 95, no. 1 (January 2011): 40–45. https://doi.org/10.1016/j.fertnstert.2010.06.059.
Near AM, Wu AH, Templeman C, Van Den Berg DJ, Doherty JA, Rossing MA, et al. Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort. Fertil Steril. 2011 Jan;95(1):40–5.
Near, Aimee M., et al. “Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.Fertil Steril, vol. 95, no. 1, Jan. 2011, pp. 40–45. Pubmed, doi:10.1016/j.fertnstert.2010.06.059.
Near AM, Wu AH, Templeman C, Van Den Berg DJ, Doherty JA, Rossing MA, Goode EL, Cunningham JM, Vierkant RA, Fridley BL, Chenevix-Trench G, Webb PM, Kjær SK, Hogdall E, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Schildkraut JM, Moorman PG, Palmieri RT, Ness RB, Moysich K, Cramer DW, Terry KL, Vitonis AF, Pike MC, Berchuck A, Pearce CL, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer) (ACS), Australian Ovarian Cancer Study Group (AOCS). Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort. Fertil Steril. 2011 Jan;95(1):40–45.
Journal cover image

Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

January 2011

Volume

95

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Receptors, Progesterone
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • International Cooperation
  • Humans