A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
Journal Article (Journal Article)
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (in BNC2). Here, we report on nine additional candidate loci (defined as having P ≤ 10⁻⁴) identified after stratifying cases by histology, which we genotyped in an additional 4,353 cases and 6,021 controls. We confirmed two new susceptibility loci with P ≤ 5 × 10⁻⁸ (8q24, P = 8.0 × 10⁻¹⁵ and 2q31, P = 3.8 × 10⁻¹⁴) and identified two additional loci that approached genome-wide significance (3q25, P = 7.1 × 10⁻⁸ and 17q21, P = 1.4 × 10⁻⁷). The associations of these loci with serous ovarian cancer were generally stronger than with other cancer subtypes. Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
Full Text
Duke Authors
Cited Authors
- Goode, EL; Chenevix-Trench, G; Song, H; Ramus, SJ; Notaridou, M; Lawrenson, K; Widschwendter, M; Vierkant, RA; Larson, MC; Kjaer, SK; Birrer, MJ; Berchuck, A; Schildkraut, J; Tomlinson, I; Kiemeney, LA; Cook, LS; Gronwald, J; Garcia-Closas, M; Gore, ME; Campbell, I; Whittemore, AS; Sutphen, R; Phelan, C; Anton-Culver, H; Pearce, CL; Lambrechts, D; Rossing, MA; Chang-Claude, J; Moysich, KB; Goodman, MT; Dörk, T; Nevanlinna, H; Ness, RB; Rafnar, T; Hogdall, C; Hogdall, E; Fridley, BL; Cunningham, JM; Sieh, W; McGuire, V; Godwin, AK; Cramer, DW; Hernandez, D; Levine, D; Lu, K; Iversen, ES; Palmieri, RT; Houlston, R; van Altena, AM; Aben, KKH; Massuger, LFAG; Brooks-Wilson, A; Kelemen, LE; Le, ND; Jakubowska, A; Lubinski, J; Medrek, K; Stafford, A; Easton, DF; Tyrer, J; Bolton, KL; Harrington, P; Eccles, D; Chen, A; Molina, AN; Davila, BN; Arango, H; Tsai, Y-Y; Chen, Z; Risch, HA; McLaughlin, J; Narod, SA; Ziogas, A; Brewster, W; Gentry-Maharaj, A; Menon, U; Wu, AH; Stram, DO; Pike, MC; Wellcome Trust Case-Control Consortium, ; Beesley, J; Webb, PM; Australian Cancer Study (Ovarian Cancer), ; Australian Ovarian Cancer Study Group, ; Ovarian Cancer Association Consortium (OCAC), ; Chen, X; Ekici, AB; Thiel, FC; Beckmann, MW; Yang, H; Wentzensen, N; Lissowska, J; Fasching, PA; Despierre, E; Amant, F; Vergote, I; Doherty, J; Hein, R; Wang-Gohrke, S; Lurie, G; Carney, ME; Thompson, PJ; Runnebaum, I; Hillemanns, P; Dürst, M; Antonenkova, N; Bogdanova, N; Leminen, A; Butzow, R; Heikkinen, T; Stefansson, K; Sulem, P; Besenbacher, S; Sellers, TA; Gayther, SA; Pharoah, PDP; Ovarian Cancer Association Consortium (OCAC),
Published Date
- October 2010
Published In
Volume / Issue
- 42 / 10
Start / End Page
- 874 - 879
PubMed ID
- 20852632
Pubmed Central ID
- PMC3020231
Electronic International Standard Serial Number (EISSN)
- 1546-1718
Digital Object Identifier (DOI)
- 10.1038/ng.668
Language
- eng
Conference Location
- United States