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Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Publication ,  Journal Article
Bolton, KL; Tyrer, J; Song, H; Ramus, SJ; Notaridou, M; Jones, C; Sher, T; Gentry-Maharaj, A; Wozniak, E; Tsai, Y-Y; Weidhaas, J; Paik, D ...
Published in: Nat Genet
October 2010

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻⁴, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10⁻⁹ and P = 4 × 10⁻¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2010

Volume

42

Issue

10

Start / End Page

880 / 884

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Polymorphism, Single Nucleotide
  • Ovary
  • Ovarian Neoplasms
  • Oligonucleotide Array Sequence Analysis
  • Middle Aged
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human
 

Citation

APA
Chicago
ICMJE
MLA
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Bolton, K. L., Tyrer, J., Song, H., Ramus, S. J., Notaridou, M., Jones, C., … Gayther, S. A. (2010). Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet, 42(10), 880–884. https://doi.org/10.1038/ng.666
Bolton, Kelly L., Jonathan Tyrer, Honglin Song, Susan J. Ramus, Maria Notaridou, Chris Jones, Tanya Sher, et al. “Common variants at 19p13 are associated with susceptibility to ovarian cancer.Nat Genet 42, no. 10 (October 2010): 880–84. https://doi.org/10.1038/ng.666.
Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, et al. Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2010 Oct;42(10):880–4.
Bolton, Kelly L., et al. “Common variants at 19p13 are associated with susceptibility to ovarian cancer.Nat Genet, vol. 42, no. 10, Oct. 2010, pp. 880–84. Pubmed, doi:10.1038/ng.666.
Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, Sher T, Gentry-Maharaj A, Wozniak E, Tsai Y-Y, Weidhaas J, Paik D, Van Den Berg DJ, Stram DO, Pearce CL, Wu AH, Brewster W, Anton-Culver H, Ziogas A, Narod SA, Levine DA, Kaye SB, Brown R, Paul J, Flanagan J, Sieh W, McGuire V, Whittemore AS, Campbell I, Gore ME, Lissowska J, Yang HP, Medrek K, Gronwald J, Lubinski J, Jakubowska A, Le ND, Cook LS, Kelemen LE, Brooks-Wilson A, Massuger LFAG, Kiemeney LA, Aben KKH, van Altena AM, Houlston R, Tomlinson I, Palmieri RT, Moorman PG, Schildkraut J, Iversen ES, Phelan C, Vierkant RA, Cunningham JM, Goode EL, Fridley BL, Kruger-Kjaer S, Blaeker J, Hogdall E, Hogdall C, Gross J, Karlan BY, Ness RB, Edwards RP, Odunsi K, Moyisch KB, Baker JA, Modugno F, Heikkinenen T, Butzow R, Nevanlinna H, Leminen A, Bogdanova N, Antonenkova N, Doerk T, Hillemanns P, Dürst M, Runnebaum I, Thompson PJ, Carney ME, Goodman MT, Lurie G, Wang-Gohrke S, Hein R, Chang-Claude J, Rossing MA, Cushing-Haugen KL, Doherty J, Chen C, Rafnar T, Besenbacher S, Sulem P, Stefansson K, Birrer MJ, Terry KL, Hernandez D, Cramer DW, Vergote I, Amant F, Lambrechts D, Despierre E, Fasching PA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Ovarian Cancer Association Consortium, Johnatty SE, Webb PM, Beesley J, Chanock S, Garcia-Closas M, Sellers T, Easton DF, Berchuck A, Chenevix-Trench G, Pharoah PDP, Gayther SA. Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2010 Oct;42(10):880–884.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2010

Volume

42

Issue

10

Start / End Page

880 / 884

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Polymorphism, Single Nucleotide
  • Ovary
  • Ovarian Neoplasms
  • Oligonucleotide Array Sequence Analysis
  • Middle Aged
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human