Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Published

Journal Article

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻⁴, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10⁻⁹ and P = 4 × 10⁻¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

Full Text

Duke Authors

Cited Authors

  • Bolton, KL; Tyrer, J; Song, H; Ramus, SJ; Notaridou, M; Jones, C; Sher, T; Gentry-Maharaj, A; Wozniak, E; Tsai, Y-Y; Weidhaas, J; Paik, D; Van Den Berg, DJ; Stram, DO; Pearce, CL; Wu, AH; Brewster, W; Anton-Culver, H; Ziogas, A; Narod, SA; Levine, DA; Kaye, SB; Brown, R; Paul, J; Flanagan, J; Sieh, W; McGuire, V; Whittemore, AS; Campbell, I; Gore, ME; Lissowska, J; Yang, HP; Medrek, K; Gronwald, J; Lubinski, J; Jakubowska, A; Le, ND; Cook, LS; Kelemen, LE; Brooks-Wilson, A; Massuger, LFAG; Kiemeney, LA; Aben, KKH; van Altena, AM; Houlston, R; Tomlinson, I; Palmieri, RT; Moorman, PG; Schildkraut, J; Iversen, ES; Phelan, C; Vierkant, RA; Cunningham, JM; Goode, EL; Fridley, BL; Kruger-Kjaer, S; Blaeker, J; Hogdall, E; Hogdall, C; Gross, J; Karlan, BY; Ness, RB; Edwards, RP; Odunsi, K; Moyisch, KB; Baker, JA; Modugno, F; Heikkinenen, T; Butzow, R; Nevanlinna, H; Leminen, A; Bogdanova, N; Antonenkova, N; Doerk, T; Hillemanns, P; Dürst, M; Runnebaum, I; Thompson, PJ; Carney, ME; Goodman, MT; Lurie, G; Wang-Gohrke, S; Hein, R; Chang-Claude, J; Rossing, MA; Cushing-Haugen, KL; Doherty, J; Chen, C; Rafnar, T; Besenbacher, S; Sulem, P; Stefansson, K; Birrer, MJ; Terry, KL; Hernandez, D; Cramer, DW; Vergote, I; Amant, F; Lambrechts, D; Despierre, E; Fasching, PA; Beckmann, MW; Thiel, FC; Ekici, AB; Chen, X; Australian Ovarian Cancer Study Group, ; Australian Cancer Study (Ovarian Cancer), ; Ovarian Cancer Association Consortium, ; Johnatty, SE; Webb, PM; Beesley, J; Chanock, S; Garcia-Closas, M; Sellers, T; Easton, DF; Berchuck, A; Chenevix-Trench, G; Pharoah, PDP; Gayther, SA

Published Date

  • October 2010

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 880 - 884

PubMed ID

  • 20852633

Pubmed Central ID

  • 20852633

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.666

Language

  • eng