Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.
BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, P(trend) = 0.003). METHODS: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. RESULTS: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, P(trend) = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. IMPACT: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.
Amankwah, EK; Kelemen, LE; Wang, Q; Song, H; Chenevix-Trench, G; Australian Ovarian Cancer Study Group, ; Beesley, J; Webb, PM; Australian Cancer Study (Ovarian Cancer), ; Pearce, CL; Wu, AH; Pike, MC; Stram, DO; Chang-Claude, J; Wang-Gohrke, S; Ness, RB; Goode, EL; Cunningham, JM; Fridley, BL; Vierkant, RA; Tworoger, SS; Whittemore, AS; McGuire, V; Sieh, W; Gayther, SA; Gentry-Maharaj, A; Menon, U; Ramus, SJ; Rossing, MA; Doherty, JA; Goodman, MT; Carney, ME; Lurie, G; Wilkens, LR; Kjær, SK; Høgdall, E; Cramer, DW; Terry, KL; Garcia-Closas, M; Yang, H; Lissowska, J; Anton-Culver, H; Ziogas, A; Schildkraut, JM; Berchuck, A; Pharoah, PDP; Ovarian Cancer Association Consortium,
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