Localization and characterization of X chromosome inversion breakpoints separating Drosophila mojavensis and Drosophila arizonae.


Journal Article

Ectopic exchange between transposable elements or other repetitive sequences along a chromosome can produce chromosomal inversions. As a result, genome sequence studies typically find sequence similarity between corresponding inversion breakpoint regions. Here, we identify and investigate the breakpoint regions of the X chromosome inversion distinguishing Drosophila mojavensis and Drosophila arizonae. We localize one inversion breakpoint to 13.7 kb and localize the other to a 1-Mb interval. Using this localization and assuming microsynteny between Drosophila melanogaster and D. arizonae, we pinpoint likely positions of the inversion breakpoints to windows of less than 3000 bp. These breakpoints define the size of the inversion to approximately 11 Mb. However, in contrast to many other studies, we fail to find significant sequence similarity between the 2 breakpoint regions. The localization of these inversion breakpoints will facilitate future genetic and molecular evolutionary studies in this species group, an emerging model system for ecological genetics.

Full Text

Duke Authors

Cited Authors

  • Cirulli, ET; Noor, MAF

Published Date

  • March 2007

Published In

Volume / Issue

  • 98 / 2

Start / End Page

  • 111 - 114

PubMed ID

  • 17194790

Pubmed Central ID

  • 17194790

International Standard Serial Number (ISSN)

  • 0022-1503

Digital Object Identifier (DOI)

  • 10.1093/jhered/esl065


  • eng

Conference Location

  • United States