Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.


Journal Article

The crystallographic structures of functional fragments of ErbBs have provided excellent insights into the geometry of growth factor binding and receptor dimerization. By placing together receptor fragments to build structural models of entire receptors, we expect to understand how these enzymes are allosterically regulated; however, several predictions from these models are inconsistent with experimental evidence from cells. The opening of this gap underlines the need to investigate intact ErbBs by combining cellular and structural studies into a full picture.

Full Text

Cited Authors

  • Roberts, SK; Tynan, CJ; Winn, M; Martin-Fernandez, ML

Published Date

  • February 2012

Published In

Volume / Issue

  • 40 / 1

Start / End Page

  • 189 - 194

PubMed ID

  • 22260688

Pubmed Central ID

  • 22260688

Electronic International Standard Serial Number (EISSN)

  • 1470-8752

International Standard Serial Number (ISSN)

  • 0300-5127

Digital Object Identifier (DOI)

  • 10.1042/bst20110632


  • eng