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Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.

Publication ,  Journal Article
Rosdahl, JA; Mourton, TL; Brady-Kalnay, SM
Published in: Mol Cell Neurosci
February 2002

Protein tyrosine phosphatase mu (PTPmu) is an adhesion molecule in the immunoglobulin superfamily and is expressed in the developing nervous system. We have shown that PTPmu can promote neurite outgrowth of retinal ganglion cells and it regulates neurite outgrowth mediated by N-cadherin (S. M. Burden-Gulley and S. M. Brady-Kalnay, 1999, J. Cell Biol. 144, 1323-1336). We previously demonstrated that PTPmu binds to the scaffolding protein RACK1 in yeast and mammalian cells (T. Mourton et al., 2001, J. Biol. Chem. 276, 14896-14901). RACK1 is a receptor for activated protein kinase C (PKC). In this article, we demonstrate that PKC is involved in PTPmu-dependent signaling. PTPmu, RACK1, and PKCdelta exist in a complex in cultured retinal cells and retinal tissue. Using pharmacologic inhibition of PKC, we demonstrate that PKCdelta is required for neurite outgrowth of retinal ganglion cells on a PTPmu substrate. These results suggest that PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth.

Duke Scholars

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

February 2002

Volume

19

Issue

2

Start / End Page

292 / 306

Location

United States

Related Subject Headings

  • Stem Cells
  • Signal Transduction
  • Retinal Ganglion Cells
  • Retina
  • Receptors, Cell Surface
  • Receptors for Activated C Kinase
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Protein Tyrosine Phosphatases
  • Protein Kinase C-delta
 

Citation

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Rosdahl, J. A., Mourton, T. L., & Brady-Kalnay, S. M. (2002). Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci, 19(2), 292–306. https://doi.org/10.1006/mcne.2001.1071
Rosdahl, Jullia A., Tracy L. Mourton, and Susann M. Brady-Kalnay. “Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.Mol Cell Neurosci 19, no. 2 (February 2002): 292–306. https://doi.org/10.1006/mcne.2001.1071.
Rosdahl JA, Mourton TL, Brady-Kalnay SM. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci. 2002 Feb;19(2):292–306.
Rosdahl, Jullia A., et al. “Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.Mol Cell Neurosci, vol. 19, no. 2, Feb. 2002, pp. 292–306. Pubmed, doi:10.1006/mcne.2001.1071.
Rosdahl JA, Mourton TL, Brady-Kalnay SM. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci. 2002 Feb;19(2):292–306.
Journal cover image

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

February 2002

Volume

19

Issue

2

Start / End Page

292 / 306

Location

United States

Related Subject Headings

  • Stem Cells
  • Signal Transduction
  • Retinal Ganglion Cells
  • Retina
  • Receptors, Cell Surface
  • Receptors for Activated C Kinase
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Protein Tyrosine Phosphatases
  • Protein Kinase C-delta